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In 1971, Kutzbach and Stokstad (25) isolated and described the enzyme, MTHFR, for the first time

Abbreviations AITD: Autoimmune thyroid disease CAT: Catalase FNA: A fine needle aspiration G-6-Pase: Glucose-6-phosphatase GD: Graves disease GM: Gut microbiota HT: Hashimotos thyroiditis IgG: Immunoglobulin G L-T4: Levothyroxine NIH: National Institutes of Health PTU: Propylthiouracil RAI: Radioactive iodine therapy SOD: Superoxide dismutase T3: Triiodothyronine T4: Thyroxine TCM: Traditional Chinese medicine TGAb: Thyroglobulin antibodies Th1/Th2: T-helper 1/T-helper 2 Th17/Treg: T-helper 17/regulatory T cells TPOAb: Thyroid peroxidase antibodies TSH: Thyroid-stimulating hormone TSI: Thyroid stimulating immunoglobulin References Abdulla J, Abubaker F, Saber F (2020) Thyroid dysfunction among adults in Bahrain: a hospital-based study

In both pathways, the enzyme S-adenosylmethionine synthase ( MAT2B ) catalyses the phosphorylation reaction of methionine to S-adenosyl-L-methionine

[DOI] [PMC free article] [PubMed] [Google Scholar] 213.Fanzo J, Davis C, McLaren R, Choufani J