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Liu HH, Balter P, Tutt T, Choi B, Zhang J, Wang C, Chi M, Luo D, Pan T, Hunjan S, Starkschall G, Rosen I, Prado K, Liao Z, Chang JY , Komaki R, Cox JD, Mohan R, Dong L

FOXO4-DRI, a novel peptide-based intervention, specifically disrupts the interaction between FOXO4 and P53, thereby inducing apoptosis in senescent cells

This parameterization of importin conformational dynamics could not have been achieved using X-ray crystallography

Since the majority of substrates for NADase- CD38 are expected to be intracellular, the ecto-enzymatic activity of this enzyme represents an intriguing topological paradox (Figure 3b)