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Ferroptosis regulation in lysosome Lysosomal iron and cathepsin B contribute to ferroptotic cell death. Lysosomal cyst(e)ine can be mobilized to maintain glutathione synthesis and glutathione peroxidase 4 activity, thereby limiting lipid peroxidation. a) Schematic representation of the ferroptosis pathway. GSH: Download Scientific Diagram Signaling pathway of ferroptosis in cardiomyocytes. The defining Download Scientific Diagram The glutathione peroxidase family: Discoveries and mechanism ScienceDirect
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