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Furthermore, effector genes GZMB , GNLY , GZMA , PRF1 , IL-2 , IFN as well as the master regulator of exhaustion TOX were significantly downregulated in rapamycin-treated CAR T products (Fig

(c) For the PBMC scRNA-seq data set, we annotated our clusters by using the Seurat reference mapping function to overlay our gene expression profiles onto the multimodal PBMC atlas