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NMDA receptors are sensitive to glutamate binding, the major excitatory neurotransmitter in the brain whose extracellular levels increase abnormally during insults, such as ischemia

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AF9, a paralog of ENL that is also bound by this chemical series 30 , was too lowly expressed in MV4;11 cells to evaluate degradation by proteomics, but an immunoblot analysis of endogenously expressed AF9 suggests it can also be degraded by dHTC1 (Extended Data Fig