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MOTS-c and exercise-induced physical decline Reynolds JC et al

Pinealon is EDR, while Epitalon is the four-amino-acid AEDG peptide

A case-control study (50 domestic shorthair cats with a confirmed diagnosis of FISS and 100 disease-free matched controls) investigating a possible association between polymorphisms in the genomic sequence of the feline p53 gene and a predisposition to FISS, found a strong association between FISS and the presence of specific nucleotides at two of the polymorphic sites (Banerji et al., 2007)

Collectively the prior work support moving forward with a Phase II, placebo-controlled study of D+Q (NCT04685590)