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Therefore, our objective was to explore the interplay between two key players in BD disease pathophysiology: mitochondrial dysfunction and inflammation

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The characteristics encompass loss of contact inhibition, expression of oncogenes, independent invasion of cartilage, and compromised apoptosis [52]

Amplification of genes encoding 1 or more of the ABC drug efflux pumps (P-glycoprotein, MRP1, or ABCG2/BCRP), can also lead to multidrug resistance phenotypes (Cole et al, 1992