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Pre-analytical oxidation can distort GSH and GSSG results

GPx4 uses GSH as a reducing substrate and converts it into oxidized form, also referred to as glutathione disulphide (GS-SG) ( NFE2L2 gene) (Habib et al., 2015), the xCT mRNA can be positively regulated by the activation of transcription factor 4 (ATF4) under oxidative stress (Sato et al., 2004), while its negative regulation by p53 results in cysteine deprivation and increased susceptibility to ferroptosis (Jiang et al., 2015)

Depression Depression is one of the most prevalent mental health disorders worldwide, affecting approximately 280 million people [486]

Endometrial-myometrial interface: relationship to adenomyosis and changes in pregnancy