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Considering the multifactorial pathogenesis of OA, future research needs to prioritize conducting early proof-of-concept clinical trials to evaluate the feasibility and synergistic effects of locally applied ferroptosis inhibitors such as Fer-1 or GPX4 activators combined with existing conservative treatments including weight management, physical therapy, and NSAIDs or emerging cell and tissue engineering therapies

Caspase-8, a major regulator of intrinsic apoptosis, blocks the ZBP1-MLKL necrosis cascade by cleaving the ZBP1-RIPK3 complex [283]

These treatments remove surface pigmentation faster than OTC products

Swanton, C