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AOD-9604 does not affect IGF-1 because it lacks the receptor-binding domains necessary to activate growth hormone receptors

This is the single fact that does the most work in separating the two compounds evidence profiles, and its worth flagging early rather than burying it

Cartilage degeneration was scored using the Yoshimi scale, which ranges from 0, defined as normal cartilage, to 5, defined as complete loss of cartilage