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We acknowledge Medicines for Malaria Venture (MMV) and the Menzies School of Health Research as a partner and thank all collaborating institutions and field teams across Indonesia and Papua New Guinea for their essential support and contributions

Isolation and culture of primary hepatocytes Primary hepatocytes were isolated from C57BL/6 J mice by a two-step collagenase method as described by Li et al (Li et al, 2010)

From a clinical application perspective, autologous mitochondrial transplantation could circumvent immune rejection issues and has demonstrated feasibility in pediatric cardiac surgery models [164], providing a valuable reference for neurological applications