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2B), suggesting that some population of cells treated with curcumin was irreversibly growth-arrested, but remained alive

Reduced ventilation due to loss of elastic recoil in the emphysematous lung, together with the loss of the capillary bed and the generalized inhomogeneity of ventilation due to the patchy nature of these changes, leads to areas of V A /Q mismatching that result in arterial hypoxemia