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Although many factors such as absorption and bioavailability profiles can influence its physiologic concentrations (61), it has long estimated that adequate intake of vitamin C of either 200 mg/day from five servings of fruits and vegetables or 100 mg/day is necessary to prevent its deficiency with a margin of safety (62)

Delayed reaction: There is also a later response that happens hours after the initial trigger of mast cell degranulation

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However, the clinical translation of these strategies requires addressing key challenges, including standardisation of treatment protocols, regulatory considerations, ethical implications, and long-term safety evaluation