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In addition, -KG can be utilized via malic enzyme to generate NADPH, a process that supports glutathione regeneration ( 2+ to Fe 3+ , facilitating the efflux of iron from cells ( 2.3 Ferroptosis and other cell death pathways Ferroptosis differs from other cell death modalities in both molecular mechanisms and morphological characteristics, since it is a unique iron-dependent type of controlled cell death triggered by LP and GPX4 inactivation (Table 1)

PMID: 243 SchmidPCortesJDentRPusztaiLMcArthurHKmmelSet al

Combination of sorafenib, idarubicin, and cytarabine has a high response rate in patients with newly diagnosed acute myeloid leukemia younger than 65 years