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Recently, it has been found that physiological doses of CO, produced during the HO-1 enzymatic reaction, can act as intracellular second messengers, promoting mitochondrial regeneration and restoring mitochondrial membrane potential, thereby reducing mitochondrial ROS production (Huang et al., 2018)

[1] The original Grand Theft Auto (1997), its expansion packs, and Grand Theft Auto 2 (1999) are set in the "2D Universe", while Grand Theft Auto III (2001), Vice City (2002), Advance (2004), San Andreas (2004), Liberty City Stories (2005), and Vice City Stories (2006) form the "3D Universe"

The peptide was discovered during research on human gastric juice

These proteins have a great implication in the regulation of structural functions of brain cell in addition to a number of cellular functions including cellular signaling, energy metabolism and detoxification