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Samples were transferred onto 0.5 m-thick silicon nitride (Si 3 N 4 ) window (Silson), excess buffer wicked away and then the slide was frozen in situ under a laminar stream of 100 K dry nitrogen (N 2 ) gas

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The development of targeted therapeutic interventions to correct epigenetic signatures, e.g., DNA methylation patterns, may therefore permanently resolve immune dysregulation and improve outcomes in psoriasis, PsA and other T-cell mediated autoimmune/inflammatory diseases (47)