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The calculated solvation energies of NAP and its metabolites, DNAP, NAP-AGLU, NAP-GLY, NAP-SU and DNAP-AGLU from PM3 calculations in kcal mol -1 are, respectively -12.26, -15.10, -17.93, -52.42 and -55.79 and their dipole moments from DFT calculations are 6.4, 6.0, 4.6, 7.1 and 6.9, respectively

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3a), although under these conditions the generation of m + 2 glutamate was not impacted by PH755 treatment in most of the cell lines tested (Supplementary Figure 3a)

They may also become more prone to insulin resistance, which represents a step toward diabetes