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The activation phase refers to ROS promoting the assembly and activation of the NLRP3 inflammasome through TXNIP

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[4] In the initiation phase, a pro-oxidant hydroxyl radical (OH) abstracts the hydrogen at the allylic position (CH 2 CH=CH 2 ) or methine bridge (=CH) on the stable lipid substrate, typically a polyunsaturated fatty acid (PUFA), to form the lipid radical (L) and water (H 2 O)