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Description

Management of the multiple symptoms of irritable bowel syndrome

6 Future research directions and challenges 6.1 Mechanistic exploration: deciphering dual roles and context-specific signaling The dual immunomodulatory effects of microbial metabolitessuch as butyrate enhancing CD8 + T cell cytotoxicity while suppressing DC functionand their receptor-specific mechanisms (e.g., SCFAs via GPR41/43, Trp derivatives via AhR/IDO1) demand systematic resolution