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TRP can be metabolized through two primary routes

CDC.gov, Candidiasis

This multifunctionality represents a paradigm shift, transforming hydrogels from passive spacers into active modulators of the tumor microenvironment, directly addressing the spatial, biological, and biochemical limitations that have historically constrained brachytherapy efficacy

Another model of hyperalgesia is the mu opioid receptor agonist-induced hyperalgesia via stimulation cAMP by PLC and the phosphoinositide signaling cascade which specifically increases prkcg activity (Park et al., 1993)