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Although cytokines are mainly produced by the immune system, there is also an unclear link between neuroinflammation and these peripheral proinflammatory cytokines (201)

The impact of these interactions on AR target gene expression is proportional to the enhancer-promoter contact frequency

2 Osteoarthritis: driven by synovitis and fibrosis Osteoarthritis is a highly prevalent musculoskeletal disorder and the most common form of arthritis