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In a study on both mice and humans, researchers found that pre-exercise glutathione administration improved lipid metabolism and acidification in the skeletal muscle of the subjects, resulting in less muscle fatigue [9]

Intriguingly, another interesting research lead to the discovery of a differential role for IRSs in apoptosis, suggesting an antiapoptotic effect for IRS-2 [122] which is consistent with known differential roles of IGF-1 and insulin