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Ishikawa T, Abe S, Watanabe T, et al

As typical for retrospective chart reviews, the outcome variables were limited to those that were systemically recorded on the patient charts during routine clinical outpatient visits, resulting in that some tests ( e.g

Because the pituitary remains largely unaffected and is able to maintain intracellular T3 levels while the rest of the body suffers from significantly reduced intracellular T3 levels, there is no elevation in thyroid-stimulating hormone (TSH) despite the presence of wide-spread tissue hypothyroidism, making the TSH and other standard blood tests a poor marker to determine the presence or absence of hypothyroidism

1995;10(Suppl 2):S329