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Aberrant vasculature resulting from tumor angiogenesis plays a critical role in the development of resistance to breast cancer treatments, via exacerbation of tumor hypoxia, decreased effective drug concentrations within tumors, and immune-related mechanisms

Deeb, S

Collectively, co-targeting metabolic dependencies (e.g., glutaminase inhibitors, ammonium scavengers) and death evasion mechanisms (e.g., ferroptosis inducers, ATF6 inhibitors) may overcome therapeutic resistance, with preclinical validation urgently needed for strategies combining autophagy modulation (AMPK/mTOR/ULK1 targeting), ferroptosis potentiation (system Xc blockade), and stromal disruption (CAF-derived glutamine inhibition) (205, 206)

A., Blumm, N., Barabsi, A.-L