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Vegans and "patients with diseases like Crohn's and colitis as well as people with pernicious anemia are also particularly vulnerable to deficiency," added Silverstein

Severe cases may last up to 6 weeks and include weight loss

Absorption is limited to approximately 1.5 g per dose through the intrinsic factor pathway, though passive diffusion allows absorption of about 1% of higher doses

If you have an underlying health condition like kidney disease, or if you take medication that interferes with B6 metabolism or absorption (such as oral contraceptives, hypertension drugs like hydralazine, and others), ask your doctor about appropriate supplement dosing