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Primary GCs in follicular fluid (FF) were collected, and one or two embryos were transferred on day 3 or day 5 following oocyte retrieval

Its neuropathological hallmarks include amyloid-beta (A) plaque deposition, NFTs composed of hyperphosphorylated tau protein, cerebral amyloid angiopathy, neuroinflammation, and progressive neurodegeneration (284)

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Downregulation or deficiency of pyruvate kinase leads to ATP depletion which in turn affects cell viability as well as accumulation of the glycolytic intermediates (2,3-diphosphoglycerate (2,3-DPG) that eventually leads to impaired glycolytic flux 46