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& El Aidy, S

CagriSema data from body composition scans in REDEFINE 1 showed that approximately 67% of total weight loss came from fat mass and 33% from lean soft tissue mass

The researchers think this is due to increased oxygen-binding capacity with higher iron.[ref] Hemochromatosis Genotype Report: HFE Gene Mutations: Access this content: An active subscription is required to access this content

This is proposed to be mediated by TRX1 oxidation by hydrogen peroxide which causes dissociation of ASK1 thereby triggering anti-apoptotic factors via downstream activation of MAPK kinase MKK3/MKK6/p38 and MKK4/MKK7/JNK pathways (Wagner et al