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Consideration needs also to be given to the appropriateness of the current threshold (EGRAC 130) used by many groups to indicate riboflavin deficiency

LB, Lewy bodies

In severe and/or resistant cases, oral drugs should be prescribed

Posttranslational modification with small ubiquitin-like modifier (SUMO) is a key regulatory protein modification in mammals, which is characterized with covalent conjugation of SUMO to specific lysine residues of target proteins [75, 76] and regulates diverse cellular processes [77]