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mGlu2 and mGlu3 receptors are also considered as candidate drug targets in the treatment of depression, but data with mGlu2/3 receptor ligands are not uniform

370,371 Although FODMAPs have been found to elicit the same gastrointestinal events in healthy people and IBS sufferers, heightened pain sensitivity in people with IBS is thought to cause them to experience symptoms like pain, distension, and bloating

93 Although berberine has been studied and shown to have a high level of safety in human clinical trials, concerns about its long-term use have been raised on the basis of preclinical studies that suggest long-term berberine use, especially at high doses, may impair cellular metabolism in specific types of cells

The nightly use of sodium oxybate is associated with a reduction in nocturnal sleep disruption: a double-blind, placebo-controlled study in patients with narcolepsy