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The signaling-regulatory role of metabolites presents promising therapeutic opportunities for rewiring cellular metabolism and improving T cell-based therapies

For example, ASD patients tend to have decreased levels of Bacteroidetes microbes, which facilitate polysaccharide digestion, and significantly higher levels of Clostridium species, which produce neurotoxins that are thought to be linked to the exacerbation of autistic symptoms (Figure 4)

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In this study, even small-sized hypopigmentation or RPE elevation showed a significant risk for exudative MNV with long-term follow-up