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Further analysis showed that this impairment of DNA synthesis is associated with alterations in the T-cell receptor (TCR) signaling, including conformational changes in TCR and LCK, reduced PLC-1 phosphorylation and calcium flux, and increased ERK phosphorylation [36]

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Oxidative Stress and Inflammation: Epitalons Antioxidant and Anti-Mutagenic Actions At the cellular level, aging isnt just about time - its about damage

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75 These insights position epigenetic mechanisms as potential therapeutic targets for mitigating hyperglycemia-induced kidney damage

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doi: 10.1016/j.jtemb.2018.02.015 [DOI] [PubMed] [Google Scholar] 64

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