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Microcirculatory dysfunction in sepsis: pathogenesis, clinical monitoring, and prospective treatments

Long-term safety with chronic use hasn't been established in rigorous clinical trials

Retatrutide's TRIUMPH-4 trial reported nausea in 38.1-43.2% of participants, dysesthesia in 8.8-20.9% (dose-dependent), and discontinuation rates of 12.2-18.2%