glutathione period Genome-wide analysis of ascorbate-glutathione cycle gene families in harvested tomato (Solanum lycopersicum) highlights their crucial role in phytohormones and stress management Hydrogen peroxide, ascorbate, and glutathione:

Mechanistically, HB101 reduced amyloid- (A) aggregation by enhancing lysosomal activity, autophagy, and mitochondrial/endoplasmic reticulum unfolded protein responses (UPRmt/UPRer)

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Cancer Lett 474:138150

With a goal of covering multiple biological systems to study effects on oxidation, the following models have been considered worth pursuing: Wild-type and mutant human GPX4 recombinant protein (available now at Karolinska Institute) CRISPR-edited GPX4 variant in reference cell lines (available now at Colombia University) SSMD patient-derived fibroblasts (available now at RUCDR Biorepository) SSMD patient-derived iPSC lines (available now at RUCDR Biorepository) Brain organoids derived from patient-derived iPSCs (not yet started) GPX4 conditional/complete knock-out mice (available now at JAX, Stock #027964) GPX4 condition knock-in mice (in-progress, ETA 1-Feb-2021) For genetic conditions, animal models are built by recreating the genetic variation in the animals genome or silencing the gene entirely