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JAMA Psychiatry 75 , 901910 (2018)

Moreover, the potential of personalized medicine in managing oxidative stress-related neurodegeneration is gaining momentum: genetic variants in the Nrf2 signaling pathway or SIRT1-mediated deacetylation affecting astrocytic GSH synthesis (e.g., regulating glutamate cysteine ligase catalytic subunit expression), combined with biomarkers like individual GSH levels and Nrf2 activity, could enable tailored interventions