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J Clin Oncol (2010) 28(20):32717

10.1038/s41467-023-41626-7 127 LyuP.WenJ.ZhangW.LiuN.StolzerI.GielA.et al (2024)

18.3328 min 340% buffer B

There is clear evidence that deficiencies in the function of insulin/IGF-1 signaling can extend lifespan, whereas an increased activity in this pathway promotes the aging process