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Phase II detoxification Conjugates with reactive metabolites (acetaminophen toxin, heavy metals) for excretion via the liver - a primary detox pathway

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While this unidirectional behavior effectively destroys cell metabolism for tumor suppression, it poses challenges because of the absence of coupling between the intracellular nanostructures and endogenous feedback mechanisms, thereby hindering their translation to scenarios requiring sustained cellular viability and precise, nondestructive function modulation, including probiotic interventions 46 , programmable cell-based therapeutics 47 and engineered living materials 48

Critical role of ASCT2-mediated amino acid metabolism in promoting leukaemia development and progression