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The results showed that patients with a mean baseline body weight of 106.9 kg who were treated with CagriSema (2.4/2.4 mg) achieved 22.7% weight loss after 68 weeks, compared to 11.8% of those treated with cagrilintide 2.4 mg monotherapy and 16.1% of those treated with semaglutide 2.4 mg monotherapy, and to 2.3% of those receiving only the placebo [125]

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We thank Christopher Koscher for his assistance with protein expression and purification and Florian Grebien for help with establishing the RPE-1 cell lines stably expressing p53 and p53 mutants

These regenerative procedures provide concentrated growth factors and progenitor cells, but their effectiveness depends on an optimal tissue environment