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Among mutations in the PIK3CA gene, about80% occur in the helical and kinase domains

doi: 10.1371/journal.pmed.1001596 46

Pharmacological modulation of Poly (ADP-ribose) polymerase-mediated cell death: exploitation in cancer chemotherapy

A unique characteristic of GGT is that it is located on the extracellular surface of mammalian cells with a catalytic active site oriented to the extracellular environment (11)