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Thus, the production of proinflammatory cytokines and tissue infiltration by myeloid cells were normal (similar to wild type) in Munc13-4-deficient mice when challenged, in vivo, with the TLR4 ligand lipopolysaccharide (LPS) 32

This is a very important distinction because white fillings, ceramic inlays, and ceramic onlays are usually NOT provided with the biomimetic approach by most providers