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Uncoupling of NOS is commonly seen when its co-factor, tetrahydrobiopterin (BH 4 ), or its substrate, L-arginine, is deficient [59]

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Iron metabolism disorder, lipid peroxidation and decreased antioxidant capacity are involved in the occurrence of ferroptosis, and several key regulators (e.g., system Xc - , GPX4, p53 and ACSL4) play an important role in monitoring ferroptosis