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its enrichment in rapidly proliferating cells leads to sorafenib resistance [90]

Moura IC, Centelles MN, Arcos-Fajardo M, Malheiros DM, Collawn JF, Cooper MD, et al

Although CHAC1 mRNA levels remain elevated, the lack of methionine, essential for initiating protein synthesis, prevents the translation of CHAC1 mRNA into functional protein