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Targeting the adenosine-mediated metabolic immune checkpoint with engineered probiotic for enhanced chemo-immunotherapy

Employing drug therapy or stem cell therapy as adjunctive treatments to hypothermia therapy holds great significance

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To confirm that tree-based ML models are the most appropriate for our analysis we also built Least Absolute Shrinkage and Selection Operator (LASSO) models to predict circulating TMAO in the left-out group using again fivefold cross-validation with all the available variables (full model) as input in BMIS ( N = 582