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OConnor, City of Hope, United States Updates Copyright 2022 Ji, Fu, Li, He and Qiu

52 Thioredoxin is a 12 kDa oxido-reductase enzyme capable of donating electrons to help reduce oxidized proteins, ribonucleotides and cell signaling molecules including p38 mitogen-activity protein kinase, NFkB and phosphatidylinositol 3 kinase

Reported effects are mild and transient: Localized irritation or redness at injection site, Mild fatigue or transient headache during initial days, Rare gastrointestinal upset (nausea, stomach discomfort)

Paradoxically, the high crystallin concentration of the lens fiber cell cytoplasm is an essential component of lens transparency