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An enlarged view from the preceding time lapse (denoted with a white box) shows an astrocyte in the glial limitans dying (white arrowhead) 45 minutes following compression injury

On one hand, cuproptotic tumor cells can directly activate their internal cyclic GMP-AMP synthase (cGAS)/stimulator of interferon genes (STING) signaling pathway, triggering the release of inflammatory factors to initiate immune responses within the TME

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The small sample size of our study is a drawback, and the reliance on self-reported measures of health and menstrual cycle length data may have introduced biases that may have affected the robustness of our findings