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The reduction of the carcinogenic chromate Cr(VI) by biological reductants such as ascorbate or glutathione results in the formation of Cr(III)-ascorbate-DNA crosslinks and binary chromium(III)DNA adducts in which chromium interacts with guanine at the N7 position (Brown et al

Red structures designate CVOs (Bassi, 2015)

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This process, known as hyperplasia, leads to the creation of new muscle fibers and increased muscle cell numbers, contributing to long-term growth potential