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ALS as a metabolic iceberg ALS may also be conceptualized as a metabolic iceberg, with the hallmark clinical, anatomical, and pathological features emerging as late-stage effects of impaired mitochondrial biology (Fig

Organochlorine insecticides in substantia nigra in Parkinsons disease

The selective depletion of GSH in this organelle can sensitize hepatocytes to the oxidative effects of cytokines such as tumor necrosis factor (TNF) [85]

The observed inconsistencies between available in planta, in vitro and in vivo (cell factory) data, however, led us to hypothesize that arGSTs might not (only) have the literature-proposed transport function but could play a central role in the biosynthetic step from leucoanthocyanidins ( 2 ) to anthocyanidins ( 3 )