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doi: 10.1038/s41598-025-97943-y 137 JiangWXieHGhoorahDShangYShiHLiuFet al

However, it is disappointing that with the consumption of intracellular GSH, the cell produces a stress response to up-regulate the biosynthesis of GSH, which will cause intracellular GSH cannot be completely exhausted and cells become resistant to GSH-consuming drugs [14]