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The specificity of MeCbl to interact with Cys180 of GSDME, which is evolutionally conserved in zebrafish, mice, and humans, together with its capability in inhibiting GSDME-mediated pyroptotic cell death across these species, strongly support that MeCbl can either be directly repurposed as a drug, or serve as a leading compound to ignite future development of specific GSDME inhibitory drugs, to prevent GSDME-mediated pyroptosis