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This preserves the natural pulsatile release pattern and negative feedback mechanisms, typically resulting in a safer side effect profile (Prakash & Bhatt, 2013, Indian Journal of Endocrinology and Metabolism )

oral administration of a single dose of 3 grams of glutathione to health humans does not increase circulating glutathione to a clinically beneficial extent (Witschi et al., The Systemic Availability of Oral Glutathione, Eur