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The peptide activates melanocortin-4 receptors in the hypothalamus and melanocortin-3 receptors in limbic circuits, triggering dopamine release and nitric oxide synthesis in arousal pathways

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Head CT conducted using a CT scanner (Aquilion Lightning/Helios i Edition, Canon Medical Systems, Tochigi, Japan) showed occipital bone destruction at the lesion site (Figure 3)